Namuhla, i-photodamage isibe yisihloko esishisayo, esingabangeli ukuguga kwesikhumba kuphela futhi sithinte ukubukeka, kodwa futhi singabangela izinkinga zempilo ezimbi. I-Mid-wave ultraviolet (UVB) iyisici esibalulekile ekudambiseni ukonakala kwesikhumba. Ingenza ama-keratinocyte asebenze ukuze akhiqize izici ezivuthayo (ezifana ne-IL-1α, PGE2), okuholela ku-erythema, ama-blisters nokunye ukulimala. Ithimba likaSolwazi Li Li weLandivine Research Institute lishicilele ucwaningo ku-China Science and Technology Core Journal “Food and Fermentation Industry”, libike ngokokuqala ngqa ukuthi i-Ganoderma-Chaga impushana eqandisiwe elungiselelwe kusetshenziswa ubuchwepheshe bokuvubela obuwuketshezi obunezindlela ezimbili busebenza kahle kakhulu ekulungiseni umonakalo wokukhanya kwe-UVB, ihlinzeka ngendlela entsha yokuthuthukiswa kwe-cosme esebenza kahle yokulwa nokuthwebula izithombe.

Ukuphumelela okubalulekile:

1. Ukuvimbela okuhlosiwe kwesiphepho esivuvukalayo: Ekugxilweni okuphephile (0.0313 mg / mL), i-Ganoderma-Chaga (S3) i-fermentation liquid powder eyomile enezinga elibaluleke kakhulu lokuvimbela ekusithekeni kwezici ezibalulekile ezivuthayo i-IL-1α kanye ne-PGE2 ngamaseli e-HaCaT abangelwa yi-UVB, yokuhlasela ngokuqondile indlela ye-photodamage.
2. Umphumela we-synergistic ucacile: ukuphumelela kwenhlanganisela ye-Ganoderma-Chaga fermentation (S3) kungcono kakhulu kune-Ganoderma fermentation yedwa (S1), ikakhulukazi ekuvimbeleni isici esinamandla sokuvuvukala nokubangela ubuhlungu PGE2, umphumela we-S3 unamandla kakhulu kune-S1 (P<0.01).
3. I-Chaga iyi-synergist eyisihluthulelo: Ngokucwaninga nokuqhathanisa izimpushana ezinhlanu zomhluzi omisiwe omisiwe we-Ganoderma (S1), i-Ganoderma-Polygonatum odoratum (S2), i-Ganoderma-Chaga (S3), i-Ganoderma-ginseng (S4), kanye ne-Ganoderma-Panax notoginseng enqunywa ukuthi i-synergastic synergastic ithuthukisa i-S5), Ikhono lokulungisa isithombe semikhiqizo ye-Ganoderma fermentation, eveza amandla enhlanganisela ethile yebhaktheriya nezidakamizwa ekulawulweni kwe-metabolic.

I-IL-1α imiphumela yokuthola okuqukethwe

Umthelela we-S1 ~ S5 kokuqukethwe kwemfihlo kwe-IL-1α

Imiphumela yokuhlolwa kwe-PGE2

Umthelela we-S1 ~ S5 kokuqukethwe okuyimfihlo kwe-PGE2

Inani lesayensi nezobuchwepheshe kanye namathemba enziwa yizimboni:

1. Izithiyo zobuchwepheshe ezisungulayo: “Isikhunta sokwelapha + izitshalo eziyisici” ubuchwepheshe bokuvutshelwa kwezindlela ezimbili bungafinyelela uguquko oluqondisayo kanye nokunothiswa kwezithako ezisebenza kakhulu, lwephule umgoqo wokusebenza ngempumelelo kwempahla eluhlaza ye-Ganoderma eyodwa.
2. Izinzuzo ezivelele zezinto ezingavuthiwe: Impushana eyomisiwe ye-S3 etholiwe inomsebenzi ozinzile, umphumela wethamo elicacile, nokuphepha okuphezulu kwezinto eziphilayo, ehlangabezana nesidingo sezinto ezibonakalayo ezisebenzayo ekunqandeni ukuthwebula izithombe, ukulungiswa ngemva kokushona kwelanga kanye nemikhiqizo yokunakekelwa kwesikhumba epholile.
3. Isisekelo esiqinile sezezimboni: Le nqubo inezinzuzo zokukhiqiza okukhulu okufana nomjikelezo omfushane, okukhiphayo okukhulu, izindleko ezilawulekayo, nekhwalithi efanayo, ebeka isisekelo sokuthuthukiswa “komthombo wokuvutshelwa” okuhlosiwe kwempahla eluhlaza ephikisana nokuthwebula enamalungelo azimele empahla yobuhlakani.

Isifinyezo socwaningo:

Lolu cwaningo lukhethe ngempumelelo i-Ganoderma-Chaga two-way fermentation (S3) njengenhlanganisela yomonakalo elwisana ne-UVB, futhi lwaqinisekisa indlela yayo yokulungisa ephumelelayo ngamamodeli amaseli. Lokhu akuhlinzeki nje ngokusekela kwesayensi nezobuchwepheshe ekusetshenzisweni kwenani eliphezulu kwezinsiza ze-Ganoderma ne-Chaga, kodwa futhi kuvula indlela entsha yokuthuthukiswa kwesizukulwane esilandelayo sezithako ezisebenzayo zezimonyo ezisebenzayo, eziluhlaza, nezihlosiwe, okubaluleke kakhulu ekuthuthukiseni ukuncintisana kwezimboni.