Ntụkwasị obi mgbu: Gịnị kpatara ceramides ị na-agbakwunye mgbe niile "yiri ka ọ naghị eme ihe ọ bụla"?

A bịa n'ịrụzi ihe mgbochi akpụkpọ ahụ, "ceramide" bụ isi ihe a ma ama. Dị ka "ike zuru oke" nke lipids na stratum corneum, ọ bụ ihe ruru 50% ma dị ka "isi nrapado" n'etiti sel. Ọ bụ kpọmkwem n'ihi ya ka enwere ike ịhazi keratinocytes ka ọ bụrụ nnukwu "mgbidi nchebe", na-ekpochi mmiri miri emi n'ime akpụkpọ ahụ mgbe ọ na-ekewapụ ihe ndị na-emetọ mpụga, ụzarị ultraviolet na ihe mkpali ndị ọzọ.

Ozugbo ceramides na-efu, mgbawa ga-apụta na "mgbidi nchebe" a: ọdịiche dị n'etiti keratinocytes ga-ebuwanye ibu, mmiri na-efunahụ ga-adịwanye ngwa ngwa, ihe mkpali ndị dị n'èzí ga-abanye ngwa ngwa. Akpụkpọ ahụ ga-apụta na ọ kpọrọ nkụ, na-enwe mmetụta na-acha ọbara ọbara, nke siri ike na nke na-agba agba, na-esikwa ike ma na-agbakọta. Nke kachasị mkpa, mmebi nke ihe mgbochi akpụkpọ ahụ abụghị ihe dị mfe "mbelata na ngụkọta nke ceramides", kama ọ bụ "nsogbu nhazi" nke sistemu lipid: ceramides ogologo ogologo (karịsịa ceramide NPs) nke ọrụ mgbochi ahụ na-adabere na ya ga-eme ka mmebi ahụ dịkwuo elu na ọdịnaya ha ga-ebelata nke ọma, ebe ụfọdụ obere-chain agaghị akwado ceramides.

Enweghị ahaghị nhata nke “obere yinye ogologo na ngafe yinye dị mkpụmkpụ” na-etinye mgbakwunye ceramide n'ọgba aghara “kpuru ìsì na adịghị arụ ọrụ”. Ọ bụrụ na ị na-achụso “ngụkọta mgbakwunye”, ị ga-ehie ụzọ mejupụta ụdị mkpirisi yinye nke karịrịla anụ ahụ, ma ọ bụ leghara igodo ogologo NP anya. Tụkwasị na nke ahụ, ọnụ ọgụgụ lipid na-apụ na ụkpụrụ nke anụ ahụ, na ihe ndị agbakwunyere ga-abụ naanị "ndị mba ọzọ efu" na enweghị ike ịbanye na usoro mgbochi ma ọlị. N'ụzọ doro anya, isi ihe na-emezi ceramide adịghị mgbe ọ bụla "na-agbakwụnye nke ukwuu" kama "na-emeju ya nke ọma": imeju nke ọma isoforms ogologo yinye na-efu efu yana kwekọọ na oke lipid nke anụ ahụ.

Ngwa agha na-emebi egwuregwu: kedu ka HitecomX™ NP ga-esi dozie adịghị ike ngwa atọ dị mkpa nke ceramide?

Na nzaghachi maka nsogbu ụlọ ọrụ nke "ọ siri ike ịbanye ogologo n'agbụ, mgbakwunye na-ekwesịghị ekwesị, na usoro anaghị akwụsi ike", HitecomX ™ NP akụrụngwa na-emepụta ihe na akụkụ atọ nke "teknụzụ, oke, na ihe oriri" iji nye azịza maka nrụzi.

1. Nkà na ụzụ ọganihu: usoro nnyefe abụọ, ogologo yinye NP nwere ike mechaa banye n'ime miri emi ma kwụsie ike.

NP ceramide ogologo ogologo (ụdị nke na-efunahụ ngwa ngwa mgbe ihe mgbochi ahụ mebiri emebi) anọwo na-eche ihe ịma aka atọ nke ịbụ " siri ike igbari, dị mfe ịmeghe, ma sie ike ịbanye" n'ihi mkpụrụ ndụ hydrophobic ya na ebe mgbaze dị elu: ọ ma ọ bụ crystallizes na flocculates na usoro, ma ọ bụ ọ na-anọ n'elu akpụkpọ ahụ. HitecomX ™ NP na-akwado ceramide NP na "shei nchekwa okpukpu abụọ" site na teknụzụ nnyefe abụọ nke "mgbakọ supramolecular + liposome encapsulation":

Mgbakọ Supramolecular: "Obere nchekwa igbe" na-eme ka nkwụsi ike

Oghere hydrophobic nke cyclodextrin nwere ike "kechie" akụkụ hydrophobic nke ceramide NP nke ọma, nke ọ bụghị naanị na-eme ka ọ dịkwuo mma, kamakwa ọ nwere ike kewapụ nnyonye anya mpụga dị ka okpomọkụ na ọkụ, zere nyocha nke akụrụngwa ma ọ bụ inactivation, na-edozi nsogbu nke "eriri na ihe isi ike na ndakọrịta" nke ceramide.

Encapsulation nke Liposome: "Skin Homologous Express" na-enweta ntinye miri emi

Na ndabere nke ntinye cyclodextrin, a na-eji liposomes maka encapsulation nke abụọ iji wuo "usoro nnyefe biphasic". The phospholipid bilayer nke liposome na-agbanwe agbanwe na nhazi nke akpụkpọ ahụ akpụkpọ anụ, nke ya na "cuticle pass" maka ceramide NP, nke nwere ike ịbanye ngwa ngwa n'ime oghere cuticle kpatara site na ngafe obere yinye ceramide. N'otu oge ahụ, ịdabere na njirimara ntọhapụ a na-achịkwa nke ndị ọbịa supramolecular na onye ọbịa, ceramide NP ga-eji nwayọọ nwayọọ wepụta ya na "stratum corneum-active epidermis-dermis Layer", na-ezere nsogbu "ntọhapụ mberede" nke na-adịkarị na mkpuchi liposome omenala, na-ekwe ka ike nrụzi na-aga n'ihu na-eme ihe, na-enweta "mmetụta miri emi na ogologo oge."

2. Ọnụ ọgụgụ ziri ezi: Megharịa nha ọla edo mbụ nke akpụkpọ ahụ, nrụzi ziri ezi bụ nrụzi n'ezie

Ntụle lipid nke stratum corneum anụ ahụ bụ "ọnọdụ dị mma" nke e guzobere site na evolushọn ogologo oge-ceramide: cholesterol: fatty acid ≈ 50:30:20. Mgbe oke nke lipids exogenous dabara nke ọma nke a, ọ na-adịkarị mfe itinye n'ime sistemu mgbochi nke anụ ahụ ma jikọta ya na lipids endogenous iji rụkwaa mmetụta. Emebere HitecomX™NP site n'izo aka na oke ala ala a, na-eme ka lipids agbakwunyere dabara adaba maka mkpa anụ ahụ.

N'ime ha, cholesterol na-enyere aka ịhazigharị njigide nke nhazi lipid ma gbochie ihe mgbochi ahụ ka ọ ghara ịdị oke ma ọ bụ tọpụ; stearic acid nwere ike imekọ ihe na ceramide NP na cholesterol iji nyere aka wulite usoro lipid kwụsiri ike ma nye “ihe mgbochi mgbochi mmiri” siri ike maka stratum corneum; na isi ceramide NP na-eme ka ọ bụrụ "njikọ na-efu efu" mgbe ihe mgbochi mebiri emebi. Ọ naghị agbakwunyere isoforms dị mkpụmkpụ nke dị mkpụmkpụ, na-elekwasị anya naanị na isi ihe mgbu nke mfu ogologo agbụ, na n'ezie "mere maka ihe na-efu."

3. Efrata maka udo nke uche: Human homologous NP + moisturizing okpukpu abụọ Buff, dabara adaba akpụkpọ anụ.

Na mgbakwunye na "ntụgharị ziri ezi na ntinye miri emi", HitecomX ™ NP na-egbokwa mkpa anụ ahụ n'ihe gbasara ihe kwesịrị ekwesị, na-ebelata ihe ize ndụ nke iwe site na isi iyi.

NP ceramide dabara mmadụ: Ọdịdị molekụla ya bụ kpọmkwem otu ceramide NP nke akpụkpọ ahụ n'onwe ya mebere. Akpụkpọ ahụ na-anabata nke ukwuu maka “ihe ndị na-emekọ ihe” na ọ gaghị amata ha dị ka “ihe mgbakasị mpụga” mana na-etinye ha ozugbo n'ime ihe mgbochi maka ndozi. Ọbụlagodi akpụkpọ ahụ nwere mmetụta siri ike nke nwere ụkọ ceramide siri ike agaghị adị mfe ịnweta ọbara ọbara na ịta ahụhụ mgbe ejiri ya.

Edobere ya na ihe na-eme ka mmiri dị n'okike (NMF): na-akpụ "mmezi + moisturize" buff okpukpu abụọ. Ceramide NP bụ maka "ịrụzi mgbidi" (ịrụghachi ihe owuwu nke stratum corneum), na NMF na-ahụ maka "ịmejupụta oghere" (ịkpọchi mmiri nke stratum corneum) - na-ezere ihere nke "ịkwụsị mmiri na-aga n'ihu n'oge usoro nrụzi", na-ekwe ka akpụkpọ ahụ nọgide na-enwe mmiri mmiri mgbe niile n'oge oge na-edozi ahụ ma na-enwe mmetụta dị nro na akpụkpọ ahụ.

Data na-ekwu maka onwe ya: ụlọ nyocha-egosipụtara, arụmọrụ ọ bụla na-eguzogide ọgwụ

Ezi uche mmezi chọrọ data nnwale siri ike iji kwado ya. A nwalere HitecomX™NP site na akụkụ ndị bụ isi dị ka akụrụngwa anụ ahụ na kemịkalụ, mmetụta ntinye, ikike nrụzi, na nchekwa. Nsonaazụ dabara ozugbo isi ihe mgbu nke ụlọ ọrụ:

1. Ihe ngosi siri ike nke anụ ahụ na kemịkalụ: Usoro ahụ jupụtara na enyi

Oke urughuru 60-80nm: ihe na-erughị nha ọla edo 100nm, na-abanye n'ime stratum corneum ngwa ngwa ma na-ezere “ịgbagharị elu”;

Zeta nwere ike 60-70mV: uru zuru oke karịrị ụkpụrụ nkwụsi ike nke 30mV, na enweghị stratification ma ọ bụ flocculation na usoro;

Ọnụego mkpuchi ≥97%: ọ fọrọ nke nta ka ọ bụrụ na ọ dịghị ihe na-emebi ihe na-arụ ọrụ, dị mma karịa nkezi ụlọ ọrụ, na nkwụsị ọ bụla nwere ike ịdị irè.

2.Ike transdermal na-arị elu: ntinye miri emi na-enweghị "mkpuchi ọcha"

E jiri ya tụnyere ceramide NP na-ekpuchighị ya, omimi ntinye ya nke awa 2 na-abawanye site na 200%, ọ nwere ike iru ngwa ngwa na-arụ ọrụ epidermal oyi akwa; ọ nwekwara ike ịnọgide na-abanye n'ime ihe karịrị awa 8, na-ezere ihere nke "mmetụta ozugbo na ọdịda ngwa ngwa".

3.Barrier nrụzi ike: Mee ka "nrụzi mpụga + mmezi ime" rụọ ọrụ

Mgbe ejiri ya na akpụkpọ ahụ nwere ihe mgbochi mgbochi nke UVB kpatara (gụnyere mmebi nke ogologo ogologo NPs na mmụba nke obere agbụ), nkwupụta nke FLG protein (protein isi maka njikọ mgbochi) mụbara site na 40% ma e jiri ya tụnyere ndị mebiri emebi, na mmetụta ahụ dị mma karịa nke 45% centella asiatica, nke na-akwado uru mmezi nke NP.

4.Safe na-adịghị ewe iwe: adabara akpụkpọ anụ

Nnwale CCK-8 egosila na ọ bụrụgodị na ntinye uche ruru 2 mg/mL, ọnụọgụ ndụ ndụ cell ka dị elu dị ka 105.83%. Ọ dịghị ihe ize ndụ nke mgbakasị ahụ na ọ dabara maka ụdị anụ ahụ dị nro.

5.Highly kwụsiri ike usoro: dakọtara na otutu usoro onunu ogwu

Mgbe agbakwunyere 10% na ude ihu, ọ na-anọgide na-edobe mgbe echekwara ya n'okpuru ọnọdụ 6 dị oke egwu dị ka -20 Celsius C na-ekpo ọkụ na 50 ° C dị elu maka ụbọchị 60; mgbe agbakwunyere 5% na mmiri bụ isi, ọ na-akwụsi ike na ebe nchekwa dị iche iche, na-emebi "ihe isi ike na nhazi usoro onunu ogwu" njedebe nke ceramides ogologo ogologo.

Nchịkọta: Oge nrụzi nkenke abịala! HitecomX™ NP na-aghọ ọkacha mmasị ọhụrụ nke ihe mgbochi na ndị na-emepụta ihe

Uru nrụzi nke ceramide adịla anya, mana "otu esi eme ka ọ dị irè" agbagwojuru ụlọ ọrụ ahụ anya ruo ọtụtụ afọ. Isi mmalite nke HitecomX™ NP bụ ijide n'ụzọ ziri ezi isi ihe mgbu nke "erughị ogologo yinye, ngafe yinye dị mkpụmkpụ, na mmeju na-ezighi ezi". Ọ na-eji teknụzụ nnyefe nke abụọ iji dozie nsogbu nke "penetration", na-eji nhazi ọla edo mbụ + NP subtype iji dozie nsogbu nke "mmejupụta n'ụzọ ziri ezi", ma na-eji otu ihe ndị ahụ dị na ahụ mmadụ dozie nsogbu nke "iji nchekwa", na-eme ceramide n'ezie "ihe nrụzi dị elu".

Maka ndị na-emepụta ihe, ọ na-agbaji site na njedebe usoro nke ceramides ma nwee ike ịmepụta ngwaahịa mmezi ezubere iche; maka ndị na-azụ ahịa, ceramides etinyere na ihu nwere ike mejupụta oghere mgbochi ahụ n'ụzọ ziri ezi, na nkụ na ọbara ọbara abụghịzi “nsogbu a na-apụghị idozi”; maka ụlọ ọrụ ahụ, o debere akara maka akụrụngwa nke "na nkà mmụta sayensị na-eme mgbanwe maka mkpa anụ ahụ" - adịghị etinye ihe ndozi dị mma iji soro usoro ahụ, kama iji dozie nsogbu n'ụzọ ziri ezi.

Ọ bụrụ na ị bụ “onye ihe mgbochi” nke na-enwe nsogbu n'afọ niile, ma ọ bụ chọọ imepụta ngwaahịa nrụzi nke ọma na nke ziri ezi, HitecomX™ NP doro anya bụ nhọrọ kacha mma kwesịrị nlebara anya.